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"Breath test": the "gold standard" for diagnosis of Helicobacter pylori

Release date:2021-07-07

   Helicobacter pylori infection is a global problem. According to statistics, the infection rate of Helicobacter pylori in the global natural population exceeds 50%. In China, this number is an astonishing 768 million. In other words, 1 out of 2 people is positive for Helicobacter pylori.

  According to the World Health Organization report, it has been confirmed that Helicobacter pylori infection is related to multi-system and multi-organ diseases. Because of its strong activity and reproductive ability, Helicobacter pylori brings common diseases such as chronic gastritis and peptic ulcer to patients. Compared with normal people, the risk of gastric cancer in patients with Helicobacter pylori infection can increase by 2 to 3 times.

  In 1994, the World Health Organization and the International Agency for Research on Cancer listed Helicobacter pylori as a Class I carcinogen of human gastric cancer.

  The traditional method of diagnosing Helicobacter pylori is to observe and sample with the help of gastroscope, but it will cause additional trauma and pain to the patient, and it will take a long time to wait. The "breath test" technology developed in the "humanized care" medical diagnosis and treatment technology needs basically solves the problem of invasive screening.

 What is a "breath test"?

  The subject takes [13C] or [14C] labeled urea. The characteristic urease secreted by Helicobacter pylori will decompose the urea to produce [13C] or [14C] labeled carbon dioxide and circulate from the lungs. Exhale, collect the carbon dioxide gas exhaled by the subject and detect it on a highly sensitive instrument. If the instrument detects carbon dioxide labeled with urea [13C] or [14C] in the exhaled gas, it can be judged that the subject has a pylorus in the stomach Helicobacter.

  The urea breath test has obvious comprehensive advantages: the method is simple, and the test environment, test equipment, and operator skills are not high; sampling is easy and patient compliance is good; compared with invasive examination, it overcomes Helicobacter pylori in the stomach "Focus distribution" may cause a positive missed diagnosis problem; compared with the antibody detection method, a positive result can be judged as a current infection and can be used for reexamination after eradication treatment; the sensitivity and specificity of this method are relatively high, and it can Accurate diagnosis of Helicobacter pylori infection.Therefore, the urea breath test is regarded as the "gold standard" for the diagnosis of Helicobacter pylori both at home and abroad.

  The breath test uses carbon isotopes [13C] and [14C] as the main tracers. As a medical method of nuclear technology, due to the minimal radiation impact on the environment, patients and doctors, the United States has exempted the radioactivity management of the 1-micron urea carbon 14 breath test in 1997. Any physician can treat it in his office. The patient underwent a urea [14C] breath test. The State Environmental Protection Administration of China also exempted the radioactivity management of the urea [14C] breath test kit in 2002.

  Carbon isotopes are abundant in nature and our bodies. Scientific research shows that the radioactive dose received by a [14C] breath test is only equivalent to the radioactive dose received by eating ten bananas or even taking a flight.

  Shenzhen CNNC Haidewei Biotechnology Co., Ltd., which hosted this conference, has been committed to the professional development of breath diagnosis. It is a high-tech enterprise with complete independent intellectual property rights and a whole industry chain system in the field of breath diagnosis.

  At present, Headway has the top scientific research team in the field of breath diagnosis technology in China, and has obtained and currently effective patents of 62 technical achievements. It is one of the top ten high-tech enterprises supported by the Shenzhen government. The company has breath Professional R&D and manufacturing strength of experimental drugs and series of testing instruments. The core products include urea [14C] breath test kits, urea [13C] capsule breath test kits, and a series of Helicobacter pylori (Hp) used with them Testers, breath hydrogen testers and other products.


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